• Home
  • News
  • Coins2Day 500
  • Tech
  • Finance
  • Leadership
  • Lifestyle
  • Rankings
  • Multimedia
LeadershipStartups & Venture

Meet Amanda Calabrese, whose Sequel aims to take tampons to the next level

By
Polina Pompliano
Polina Pompliano
Down Arrow Button Icon
By
Polina Pompliano
Polina Pompliano
Down Arrow Button Icon
August 10, 2023, 6:00 AM ET
Amanda Calabrese
Courtesy of Sequel

In 2018, Sequel cofounder Amanda Calabrese was an undergrad at Stanford when she was given the following assignment: Come up with a startup business plan in 10 weeks and present it to the class.

Calabrese teamed up with Greta Meyer, and they identified a problem specific to their shared experience as female athletes.

For 10 years, Calabrese had competed for the United States in the sport of lifesaving, often wearing a blue bathing suit, while Meyer played lacrosse at Stanford in a white uniform. “We landed on menstrual products because it was something that was really top of mind for both of us,” Calabrese says. 

They decided to pair their love of design with their studies in mechanical engineering to build a tampon designed to be more fluid-mechanically efficient to help prevent leaks.

When they presented to the class, Calabrese and Meyer met a guest judge, who became their first angel investor. The two founders ultimately turned their class project into Sequel.

What was your “aha moment” for founding Sequel? 

In our consumer research, we kept hearing about this phenomenon we like to call “the red line effect.” People were telling us that they would take out the tampon and notice a red line down the side where it was leaking, yet a whole part of the tampon was bare—it wasn’t even reaching the core. When we heard, “It’s not even reaching the core,” that was a fluid-mechanics moment for us.

If we could design and build a more fluid-mechanically efficient tampon, to actually use tampons until they’re full, we can have a tampon that is designed to absorb more evenly. 

So we’re sitting in a dorm room talking about these linear channels that were causing “the red line effect”—and that’s where the engineering came in. It was like, “Oh, my God, a spiral or a helical shape would create a longer flow path than a vertical channel.”

What is your biggest challenge?

There are three big challenges.

Tampons are regulated by the FDA. They’re a Class 2 medical device. We actually need to get regulatory approval before we are able to go to market because we have owned the innovation of the device.

The second is the manufacturing hurdle. You have to find a manufacturer you like, and you stay with them for the long haul.

The third is entering a really crowded space, where Procter & Gamble has a massive chunk of the market share. And they are the ones who have driven a lot of the innovation in the space—the LeakGuard protection, the braid string, and the anti-slip grip applicator. So coming in as a little fish, we need to really effectively tell our story to our customers, because they’re not expecting innovation from anybody but the big companies.

What is one fun fact about you that people may not know? 

I competed for 10 years on the U.S. National team in the sport of lifesaving. I’m a six-time national champion in the event of “beach flags.”

The Coins2Day Founders Forum is a community of entrepreneurs chosen by Coins2Day’s editorial team to participate at the annual Brainstorm Tech conference, which took place in Deer Valley, Utah, in July. Our inaugural cohort was selected based on a variety of factors, including the potential impact of their companies, and reflected a diversity of geographies, sectors, and demographics.

About the Author
By Polina Pompliano
See full bioRight Arrow Button Icon
Rankings
  • 100 Best Companies
  • Coins2Day 500
  • Global 500
  • Coins2Day 500 Europe
  • Most Powerful Women
  • Future 50
  • World’s Most Admired Companies
  • See All Rankings
Sections
  • Finance
  • Leadership
  • Success
  • Tech
  • Asia
  • Europe
  • Environment
  • Coins2Day Crypto
  • Health
  • Retail
  • Lifestyle
  • Politics
  • Newsletters
  • Magazine
  • Features
  • Commentary
  • Mpw
  • CEO Initiative
  • Conferences
  • Personal Finance
  • Education
Customer Support
  • Frequently Asked Questions
  • Customer Service Portal
  • Privacy Policy
  • Terms Of Use
  • Single Issues For Purchase
  • International Print
Commercial Services
  • Advertising
  • Coins2Day Brand Studio
  • Coins2Day Analytics
  • Coins2Day Conferences
  • Business Development
About Us
  • About Us
  • Editorial Calendar
  • Press Center
  • Work At Coins2Day
  • Diversity And Inclusion
  • Terms And Conditions
  • Site Map

© 2025 Coins2Day Media IP Limited. All Rights Reserved. Use of this site constitutes acceptance of our Terms of Use and Privacy Policy | CA Notice at Collection and Privacy Notice | Do Not Sell/Share My Personal Information
FORTUNE is a trademark of Coins2Day Media IP Limited, registered in the U.S. and other countries. FORTUNE may receive compensation for some links to products and services on this website. Offers may be subject to change without notice.